近日，司法鑒定科學研究院嚴慧課題組許琳灝老師，使用IPHASE品牌產品：人肝微粒體在《Journal of Analytical Toxicology》權·威期刊上發(fā)表文章《In vitro and in vivo metabolic study of three new psychoactive β-keto-arylcyclohexylamines 》，影響因子2.5！
 

　　本論文中，利用斑馬魚和人肝微粒體建立體外和體內模型，研究了三種苯換利定類物質的體外和體內代謝，采用液相色譜-高分辨率質譜法分析一相和二相代謝物，總共鑒定出49種代謝物。
 

　　摘要
 

　　Since the 2000s, an increasing number of new psychoactive substances have appeared on the illicit drug market. β-ketoarylcyclohexylamine compounds play important pharmacological roles in anesthesia; however, because these new psychoactive substances have rapidly increasing illicit recreational use, the lack of detailed toxicity data are of particular concern. Therefore, analysis of their metabolites can help forensic personnel provide references and suggestions on whether a suspect has taken an illicit new psychoactive β-keto arylcyclohexylamine. The present study investigated the in vitro and in vivo metabolism and metabolites of three β-ketoarylcyclohexylamines: deschloro-N-ethyl-ketamine, fuoro-N-ethyl-ketamine and bromoketamine. In vitro and in vivo models were established using zebrafsh and human liver microsomes for analysis of Phase I and Phase II metabolites by liquid chromatography–high-resolution mass spectrometry. Altogether, 49 metabolites were identifed. The results were applied for the subject urine samples of known fuoro-N-ethyl ketamine consumer screen analysis in forensic cases. Hydroxy-deschloro-N-ethyl-ketamine, hydroxy-fuoro-N-ethyl-ketamine and hydroxy-bromoketamine were recommended as potential biomarkers for documenting intake in clinical and forensic cases.
 

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